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What is a Rheumatoid Arthritis?

Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disease that damages the joints of individuals that suffer from this condition. Inflammation primarily occurs within the lining (synovial membrane) of skeletal joints, eventually leading to cartilage and bone loss accompanied by deformation and loss of function. Joints of the hands, feet, and neck are most often affected though larger joints such as the knee may be involved. While RA is predominantly a disease of the joints damage to the skin, lungs, heart, and other organs can occur.

There are four stages of Rheumatoid Arthritis:

Stage 1

Early stage RA is notable by the presence of synovial membrane inflammation, which results in joint swelling and pain on motion.

Stage 2

In moderate stage RA, there is T and B cell proliferation and angiogenesis in the synovium. Synovial tissue starts to grow into the joint cavity, across cartilage, which will be gradually destroyed.

Stage 3

This stage is characterized by the accumulation of synovial fluid polymorphonuclear leukocytes (SFPMNs), as well as synovial cell proliferation.

Stage 4

End-stage RA disease results in a cessation of inflammatory processes. The formation of fibrous tissue and/or bone ankylosing (fusing of bone) results in ceased joint function.


What are the Typical Symptoms/Complications of Rheumatoid Arthritis?

Joint pain and swelling

Fatigue, anemia or malaise

Skin lumps or redness

Stiffness, especially after sitting or resting for longer periods of time


What causes Rheumatoid Arthritis?

Immune system cells move from the blood into the joints and joint-lining tissue, called synovium. Once they arrive, those immune system cells create inflammation that leads to irritation, which wears down cartilage. As the cartilage wears down, the space between the bones narrows. As it gets worse, the bones could rub against each other.
Inflammation of the joint lining causes swelling and fluid build-up within the joint. As the lining expands, it can damage the bone. All of these things cause the joint to become very painful, swollen, and warm to the touch.

TruStem Cell Therapy™

What type of stem cells are used and why?

TruStem Cell Therapy provides access to treatment that utilizes a patient’s stem cells isolated from their own bone marrow. There are multiple inherent benefits afforded by the utilization of bone marrow derived stem cells including their ability to differentiate into a broad variety of cells types (neurons, bone, cartilage, muscle, tendon, etc.), they are present at comparatively much higher levels than other stem cell types, possess unique immune-modulating properties, and they do not endanger a patient’s health the way other stem cells might.

What steps are involved in receiving treatment through TruStem Cell TherapyTM?

There are three steps involved:
  1. Harvest

    First a blood draw is performed followed by a minimally invasive bone marrow harvest via the iliac crest. Approximately 100cc’s of a patient’s own bone marrow is harvested through a minimally invasive, bone marrow aspiration procedure. TruStem Cell Therapy utilizes a powered bone marrow access system combined with local anesthetic allowing for consistently larger specimen of cells, extremely low levels of pain/invasiveness reported by most patients, and higher levels of sterility.


    ● Bone marrow aspirate is preferentially utilized because it is one of the richest, most accessible sources of stem cells in the human body and falls within the FDA guidelines of minimal manipulation.

  2. Process + Activate

    Both the blood and bone marrow are immediately delivered to our dedicated, onsite laboratory staffed by our team of technicians. Once your sample is in the lab our advanced proprietary process isolates and excites regenerative cells and concentrates healing factors to hyper-physiological levels in order to facilitate the creation of a highly effective, injectable therapeutic.


    ● Stem cell activation is part of what makes TruStem Cell Therapy unique. The activation procedure is designed to augment efficacy.

  3. Administer

    TruStem Cell Therapy utilizes both systematic and novel administration methods to fully saturate the body with stem cells while targeting specific areas of injury.

How are stem cells administered back into Rheumatoid Arthritis patients through TruStem Cell Therapy?

RA patients who receive stem cell therapy through us can receive both systemic and targeted administration methods:

  • Systemic IV infusion of their stem cells to fully saturate the entire body.

  • Intra articular joint injections to target the affected joints

What is unique about receiving stem cell therapy through TruStem Cell Therapy™ for RA?

  • Our focus is safety, efficacy, and patient-­centric care when providing access to superior stem cell therapy.

  • We utilize only board certified surgeons, physicians and accredited clinicians to provide care for patients.

  • Laboratory protocols are developed and refined by our PhD Neuroscientist.

  • A clinical team with expertise in practicing cellular ­based medicine.

  • Accredited Surgical Centers for enhanced procedural and patient safety

  • Targeted administration methods that direct stem cells toward specific

  • Skilled Patient Advocates who are trained to provide truthful, realistic expectations resulting from stem cell therapy. We do not make outlandish promises of cures or inaccurate claims related to improvement rates.


Can this treatment cure Rheumatoid Arthritis?

It is important for patients and caregivers to understand that current therapies, including stem cell treatment, does not provide a cure for Rheumatoid Arthritis. However, TruStem cell therapy does have the potential to improve a patient’s quality of life by reducing symptoms and complications related to RA as well as slowing its progression.

Are stem cells FDA approved for Rheumatoid Arthritis?

The FDA has not approved stem cell therapy for RA. Currently, stem cell therapy is considered “experimental.” As noted above, studies have demonstrated the safety and efficacy of stem cell therapy for this condition but additional studies are needed before FDA approval can be secured.

What type of improvements can I expect from stem cell therapy?

It is possible through these treatments, to improve a patient’s quality of life by minimizing disease related symptoms and complications.  For Rheumatoid Arthritis patients, it is possible to see improvements in any one or multiple disease related complications such as: joint pain, joint swelling, joint weakness, fatigue, anemia, etc…  If you have questions regarding how these treatments may help you, please contact one of our Patient Advocates to learn more.

How long will it take to see improvements?

It is difficult to predict the timeline of a patient’s response. Every patient responds differently to treatment. It could take weeks to months for the stem cells to provide noticeable results.

What type of side-effects can a patient expect from stem cell therapy?

Typically patients will experience some level of soreness and bruising lasting roughly a week as a result of the bone marrow harvesting procedure. Additional complications have not been observed. Over a hundred studies and clinical trials have demonstrated the safety and minimal side-­effect profile of stem cell therapy.

Let’s discuss your options.